The Medical Letter on Drugs and Therapeutics
Pralatrexate (Folotyn) for Peripheral T-Cell Lymphoma
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The FDA has approved pralatrexate (Folotyn – Allos), an intravenous (IV) antifolate, for treatment of adults with relapsed or refractory peripheral T-cell lymphoma (PTCL). It is the first drug approved by the FDA specifically for this indication.

MECHANISM OF ACTION — Pralatrexate is structurally related to methotrexate, but has a stronger affinity for dihydrofolate reductase. Inhibition of dihydrofolate reductase leads to cell death.

PERIPHERAL T-CELL LYMPHOMA — PTCLs account for 10-15% of newly diagnosed cases of non- Hodgkin’s lymphoma (NHL) in North America.1 The most common subtypes are PTCL not otherwise specified (PTCL-NOS), anaplastic large cell lymphoma and angioimmunoblastic T-cell lymphoma, which has the best prognosis of the three. T-cell lymphomas are generally more aggressive than their B-cell counterparts; PTCL-NOS has a median overall survival of ... more      

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Title: Pralatrexate (Folotyn) for Peripheral T-Cell Lymphoma
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