The Medical Letter on Drugs and Therapeutics
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1345
Three New Drugs for Hereditary Angioedema
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In the past 2 years, the FDA has approved 3 new drugs for prevention or treatment of hereditary angioedema (HAE) in non-pregnant adolescents and adults: the C1 esterase inhibitor Cinryze for prophylaxis and the C1 esterase inhibitor Berinert and the kallikrein inhibitor ecallantide (Kalbitor) for treatment of acute attacks.

THE DISEASE — HAE is a rare autosomal dominant disorder (estimated prevalence 1:10,000-50,000) in which patients experience recurrent and frequently unpredictable attacks of angioedema lasting 3-5 days and typically involving the extremities, gastrointestinal tract, genitalia, face, oropharynx or larynx. Laryngeal edema may be life-threatening. Gastrointestinal attacks are associated with severe pain, nausea, vomiting and diarrhea, and may be confused with a surgical abdomen. HAE is usually caused by a mutation of the C1-inhibitor (C1-INH) gene. C1-INH is a serine ... more      

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Title: Three New Drugs for Hereditary Angioedema
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