The Medical Letter on Drugs and Therapeutics
FROM
ISSUE
1345
An Expanded Pneumococcal Vaccine (Prevnar 13) for Infants and Children
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.

The FDA has licensed a 13-valent conjugate pneumococcal vaccine (PCV13; Prevnar 13 – Pfizer) for the prevention of invasive pneumococcal disease (IPD) in infants and children <6 years old. It replaces Prevnar (PCV7). An unconjugated 23-valent polysaccharide vaccine (PPSV23; Pneumovax 23 – Merck) is FDA-approved for use in adults.

THE NEW VACCINEPrevnar 13 contains the polysaccharides of the capsular antigens of the 7 serotypes included in PCV7 (serotypes 4, 6B, 9V, 14, 18C, 19F and 23F) and 6 additional serotypes (1, 3, 5, 6A, 7F, and 19A), each conjugated to a nontoxic diphtheria carrier protein (CRM197). The vaccine contains an aluminum phosphate adjuvant and is thimerosal-free. It is available as a pre-filled syringe for intramuscular injection.

INVASIVE PNEUMOCOCCAL DISEASE — IPD remains a leading cause of serious illness and death in ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscribe
Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: An Expanded Pneumococcal Vaccine (Prevnar 13) for Infants and Children
Article code: 1345c
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian