The Medical Letter on Drugs and Therapeutics
Tribenzor for Hypertension
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Many patients with hypertension require more than one drug to control their blood pressure.1 Tribenzor (Daiichi Sankyo), recently approved by the FDA for treatment of hypertension, combines the calcium channel blocker amlodipine (Norvasc, and others), the angiotensin receptor blocker (ARB) olmesartan (Benicar) and the most commonly prescribed diuretic, hydrochlorothiazide (HCTZ). Tribenzor is not approved for initial therapy, but is recommended for patients not adequately controlled on any 2-drug combination of a calcium channel blocker, an ARB or a diuretic.

CLINICAL STUDY — In a randomized, double-blind clinical trial in 2492 patients with hypertension (mean baseline 169/101 mm Hg), Tribenzor was compared to treatment with all possible pairs of its individual components, all titrated up to their highest strengths (40 mg olmesartan, 10 mg amlodipine ... more      

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