The Medical Letter on Drugs and Therapeutics
Natazia - A New Oral Contraceptive
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The FDA has approved the marketing of Natazia (Bayer), a 4-phase oral contraceptive containing the estrogen estradiol valerate and the progestin dienogest, both used for the first time in the US for this indication.

ORAL CONTRACEPTIVES — Most oral contraceptives available in the US are a combination of the synthetic estrogen ethinyl estradiol and a progestin. Monophasic oral contraceptives contain fixed doses of estrogen and progestin in each active pill. Multiphasic oral contraceptives vary the dose of one or both hormones during the pill cycle and generally have a lower total hormone dose per cycle.

DOSAGE — The recommended dosage of this new combination includes an estrogen step-down and a progestin step-up; days 1-2: estradiol valerate 3 mg alone; days 3-7: estradiol valerate 2 mg/dienogest 2 mg; days 8-24: estradiol valerate 2 mg/dienogest 3 mg; days 25-26: estradiol valerate 1 mg ... more      

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Title: Natazia - A New Oral Contraceptive
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