The Medical Letter on Drugs and Therapeutics
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Ceftaroline Fosamil (Teflaro) - A New IV Cephalosporin

The FDA has approved ceftaroline fosamil (Teflaro – Forest), an intravenous (IV) cephalosporin, for treatment of acute bacterial skin and skin structure infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA), and for treatment of community-acquired bacterial pneumonia in adults. It is the first beta-lactam antibiotic approved for treatment of MRSA.

MECHANISM OF ACTION — Like other beta-lactams, ceftaroline binds to penicillin-binding proteins (PBPs), inhibiting cell wall synthesis. Unlike other currently available beta-lactams, it has a high affinity in vitro for PBP2a, a unique PBP encoded by the mecA gene in MRSA.1

STANDARD TREATMENT2Skin and Skin-Structure InfectionUncomplicated skin and skinstructure ... more      

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