The Medical Letter on Drugs and Therapeutics
Duloxetine (Cymbalta) for Chronic Musculoskeletal Pain
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Previously approved by the FDA for treatment of depression, general anxiety disorder, diabetic peripheral neuropathic pain and fibromyalgia,1,2 duloxetine (Cymbalta – Lilly) has now also been approved for treatment of chronic musculoskeletal pain.

MECHANISM OF ACTION — Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). Its mechanism of action in reducing pain is unknown.

CLINICAL STUDIES — Chronic Low Back Pain – Three double-blind, randomized, 3-month trials of duloxetine in a total of >1000 patients with chronic (≥6 months) low back pain have been published and are summarized in the package insert.3-5 All were conducted by employees of the manufacturer. Two of the three trials found duloxetine more effective than placebo in reducing pain, as measured by Brief Pain ... more      

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Title: Duloxetine (Cymbalta) for Chronic Musculoskeletal Pain
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