The Medical Letter on Drugs and Therapeutics
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Azilsartan Medoxomil (Edarbi) - The Eighth ARB
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The angiotensin receptor blocker (ARB) azilsartan medoxomil (Edarbi – Takeda) was recently approved by the FDA for oral treatment of hypertension, either alone or combined with other drugs. It is the eighth ARB approved for this indication.

ARBs — ARBs are widely used for treatment of hypertension; they are generally as effective as ACE inhibitors in reducing blood pressure, and are better tolerated. It is unclear whether all ARBs are clinically equivalent; some have been shown to improve clinical outcomes in patients with cardiovascular disease or diabetes. Losartan (Cozaar, and others) is currently the only ARB available generically.1

CLINICAL STUDIES — The approval of azilsartan was based on 7 randomized, double-blind trials in almost 6000 patients with hypertension. One study in 1291 patients found that 80 mg of azilsartan ... more      

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