The Medical Letter on Drugs and Therapeutics
Peginterferon Alfa-2b (Sylatron) for Melanoma
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The FDA has approved peginterferon alfa-2b (Sylatron – Merck) for adjuvant treatment of node-positive melanoma after surgical resection. Pegylated interferon has a longer duration of action than interferon alfa-2b (Intron A), which is also FDA-approved for adjuvant treatment of malignant melanoma after surgery, and can be given once a week, compared to 3-5 times a week for standard interferon.

A CLINICAL STUDY — Approval was based on an open-label study of 1256 patients with resected stage III melanoma who were randomized to observation alone or to treatment with peginterferon alfa-2b for up to 5 years. Median recurrence-free survival was significantly longer in the peginterferon group compared to the observation group (34.8 vs. 25.6 months). Overall survival, a secondary endpoint, was not significantly different between the two groups. ... more      

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Title: Peginterferon Alfa-2b (Sylatron) for Melanoma
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