The Medical Letter on Drugs and Therapeutics
Do Calcium Supplements Increase the Risk of Myocardial Infarction?
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Supplemental calcium is recommended for prevention of postmenopausal osteoporosis in women with an inadequate dietary intake of calcium.1 The safety of calcium supplements has recently been questioned; patients may ask if they should continue to take them. The source of this concern was the publication of 2 meta-analyses in the British Medical Journal.2,3

TWO META-ANALYSES — The first meta-analysis searched other meta-analyses and clinical trial registries for placebo-controlled trials of calcium supplements. The primary endpoint of the studies included in the meta-analysis was prevention of osteoporosis or colorectal cancer. The authors obtained data on cardiovascular outcomes from self reports, hospital admissions and death certificates.

The second meta-analysis took data from a subset of women in the Women’s Health Initiative study ... more      

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Title: Do Calcium Supplements Increase the Risk of Myocardial Infarction?
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