The Medical Letter on Drugs and Therapeutics
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1382
Beta-Adrenergic Blockers and Breast Cancer
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Three retrospective studies have recently reported an association between beta-blocker use and a reduction in breast cancer metastasis and recurrence. No prospective, randomized trials have been published.1

MECHANISM OF ACTION — Activation of the beta-adrenergic receptor has been implicated in multiple steps of metastasis formation, including tumor cell proliferation, angiogenesis, and migration of tumor cells through the extracellular matrix. In a mouse model, beta-adrenergic activation had a negligible effect on primary breast tumor growth, but increased metastasis 30-fold.2

THE STUDIES — One retrospective study evaluated beta-blocker use in 466 women with early-stage breast cancer. Among these women, 43 had been treated with a beta blocker (propranolol, atenolol, bisoprolol or timolol) for hypertension, and 49 had ... more      

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Title: Beta-Adrenergic Blockers and Breast Cancer
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