The Medical Letter on Drugs and Therapeutics
Intranasal Ketorolac (Sprix)
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An intranasal formulation of ketorolac tromethamine (Sprix – Lutipold) has been approved by the FDA for short-term (up to 5 days) treatment of moderate to moderately severe pain in adults. It is the first nonsteroidal anti-inflammatory drug (NSAID) to become available in an intranasal formulation. Ketorolac tromethamine is also available in oral, ophthalmic and injectable formulations.1

NSAIDS FOR PAIN — Use of an NSAID in addition to an opioid analgesic for management of postoperative pain has been shown to improve pain control and reduce opioid use, but administration of an oral NSAID may not be possible immediately after surgery. Intravenous or intramuscular (IM) ketorolac has been shown to be comparable in analgesic efficacy to moderate doses of morphine, but can cause severe gastrointestinal toxicity and is not recommended for more than 5 ... more      

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Title: Intranasal Ketorolac (Sprix)
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