The Medical Letter on Drugs and Therapeutics
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Edarbyclor: An ARB/Chlorthalidone Combination for Hypertension

The FDA has approved a fixed-dose combination of the angiotensin receptor blocker (ARB) azilsartan and the thiazide-like diuretic chlorthalidone as Edarbyclor (Takeda) for treatment of hypertension.

THE ARB — Azilsartan medoxomil (Edarbi) was the eighth ARB to become available in the US for treatment of hypertension.1 The results of some studies have suggested that azilsartan might be slightly more effective than some other ARBs in lowering blood pressure.2

THE DIURETIC — Chlorthalidone is 1.5-2 times more potent than hydrochlorothiazide (HCTZ) and has a longer duration of action that persists throughout the nighttime hours.3 In a study that measured 24-hour ambulatory blood pressure, chlorthalidone 25 mg was more effective in lowering blood pressure than HCTZ 50 ... more      

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