The Medical Letter on Drugs and Therapeutics
FROM
ISSUE
1389
Ingenol Mebutate (Picato) for Actinic Keratoses
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.

The FDA has approved ingenol mebutate (Picato – Leo) for topical treatment of actinic keratoses (AKs). The new drug is derived from the sap of the Euphorbia peplus plant, a traditional folk remedy for warts and other skin lesions.

ACTINIC KERATOSES — Abnormal keratinocyte proliferation, typically caused by long-term UV exposure, can cause red, scaly actinic keratosis lesions, which are a marker for possible "field cancerization" of the skin, indicating an increased risk for squamous cell carcinoma (SCC).1,2

Field therapy with topical fluorouracil (5-FU) or imiquimod is highly effective and treats subclinical AKs, but both of these agents require weeks to months of administration and can cause disfiguring erythema, blisters and ulceration over a period of several months. Other treatments include diclofenac gel, which is relatively well tolerated but only ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscribe
Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: Ingenol Mebutate (Picato) for Actinic Keratoses
Article code: 1389c
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian