The Medical Letter on Drugs and Therapeutics
FROM
ISSUE
1392
Peginesatide (Omontys) for Anemia in Chronic Kidney Disease
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.

The FDA has approved the erythropoiesis-stimulating agent (ESA) peginesatide (Omontys – Affymax/Takeda), a synthetic peptide analog of erythropoietin, for treatment of anemia in patients with chronic kidney disease (CKD) who are on dialysis. Peginesatide is the third ESA to become available in the US. Overuse of the other two, which have broader indications, has been a concern.1,2

Labels for all three ESAs include a boxed warning stating that in controlled trials, patients experienced a greater risk for death, stroke and other serious cardiovascular events when ESAs were used to raise hemoglobin levels to more than 11 g/dL in patients with CKD, and that no trial has identified a hemoglobin target level that would decrease these risks.

CLINICAL STUDIES — Two unpublished, open-label, studies, both available only as abstracts, compared peginesatide with epoetin ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscribe
Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: Peginesatide (Omontys) for Anemia in Chronic Kidney Disease
Article code: 1392b
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian