The Medical Letter on Drugs and Therapeutics
Mifepristone (Korlym) for Cushing's Syndrome
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The FDA has approved the antiprogestin mifepristone (Korlym – Corcept Therapeutics) for control of hyperglycemia secondary to hypercortisolism in adults with endogenous Cushing's syndrome who have type 2 diabetes/glucose intolerance and have not responded to, or are not candidates for, surgery. Formerly known as RU 486, mifepristone is also available in a lower strength as Mifeprex for use in terminating an early intrauterine pregnancy.

MECHANISM OF ACTION — Mifepristone is a synthetic steroid with a high affinity for progesterone receptors that acts as an antiprogestin. At higher doses, it also binds strongly to glucocorticoid receptors and, to a lesser extent, androgen receptors.

TREATMENT OF CUSHING'S SYNDROME — The definitive treatment of Cushing's syndrome is surgical removal of the pituitary or adrenal tumor causing the excessive production of cortisol. The ... more      

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Title: Mifepristone (Korlym) for Cushing's Syndrome
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