The Medical Letter on Drugs and Therapeutics
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1395
Pertuzumab (Perjeta) for HER2-Positive Metastatic Breast Cancer
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Pertuzumab (Perjeta – Roche/Genentech), a humanized monoclonal antibody, has been approved by the FDA for use in combination with trastuzumab (Herceptin) and docetaxel (Taxotere, and others) for first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer.

MECHANISM OF ACTION — HER2, a transmembrane receptor protein involved in normal cell growth, is overexpressed in about 15-20% of breast cancers.1,2 Increased amounts of HER2 protein on the surface of breast cancer cells contribute to cancer cell growth and survival, and are typically associated with more aggressive disease and reduced survival.3 Pertuzumab binds to the HER2 receptor and inhibits its pairing (dimerization) with other HER receptors on the surface of cells, resulting in a blockade of HER2 signaling, cell ... more      

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Title: Pertuzumab (Perjeta) for HER2-Positive Metastatic Breast Cancer
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