The Medical Letter on Drugs and Therapeutics
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PSA Reconsidered

Three recent publications have focused attention once more on the contentious question of whether men should be screened for prostate cancer by measuring serum concentrations of prostate specific antigen (PSA).

USPSTF RECOMMENDATION — The United States Preventive Services Task Force (USPSTF) has updated its 2008 recommendation in which it advised against PSA screening in men ≥75 years old. Now it recommends against PSA-based screening in men of any age because, in effect, the benefits have not been shown to outweigh the harms of subsequent diagnostic procedures and treatments.1

SOME EXPERTS DISAGREE — In the same issue of the same journal, an ad hoc group of urologists, oncologists, other specialists and primary care physicians expressed its disagreement with the USPSTF recommendation. This group pointed out that since widespread PSA testing began in the ... more      

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