The Medical Letter on Drugs and Therapeutics
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ISSUE
1402
Pneumococcal Vaccine for Adults
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The US Advisory Committee on Immunization Practices (ACIP) has recommended that adults with immunocompromising conditions receive the 13-valent pneumococcal conjugate vaccine (PCV13; Prevnar 13), even if they have already received the older 23-valent unconjugated vaccine (PPSV23; Pneumovax 23).1 Prevnar 13, initially approved by the FDA for use in infants and young children,2 has been licensed since December 2011 for adults ≥50 years old.

PNEUMOCOCCAL DISEASE — The pneumococcal serotypes in PCV13 cause about two-thirds of the cases of invasive pneumococcal disease (IPD) in children <5 years old and about half of those in immunocompromised adults. The incidence of pneumococcal pneumonia, bacteremia, and meningitis is about 10 times higher in patients ≥65 years old than in young adults. In immunocompromised adults, ... more      

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Title: Pneumococcal Vaccine for Adults
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