A 4-Drug Combination (Stribild) for HIV
A 4-Drug Combination (Stribild) for HIV
November 26, 2012 (Issue: 1404)
The FDA has approved a fixed-dose combination of
the integrase strand transfer inhibitor (INSTI) elvitegravir,
the pharmacokinetic enhancer cobicistat, and
the nucleoside/nucleotide reverse transcriptase inhibitors
(NRTIs) emtricitabine and...more
1. Two new drugs for HIV infection. Med Lett Drugs Ther 2008; 50:2.
2. Drugs for HIV infection. Treat Guidel Med Lett 2011; 9:29.
3. Panel of Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. March 27, 2012. Available at www.aidsinfo.nih.gov. Accessed November 14, 2012.
4. PE Sax et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet 2012; 379:2439.
5. E DeJesus et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavirboosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet 2012; 379:2429.
6. C Garrido et al. Broad phenotypic cross-resistance to elvitegravir in HIV-infected patients failing on raltegravir-containing regimens. Antimicrob Agents Chemother 2012; 56:2873.
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