The Medical Letter on Drugs and Therapeutics
Mirabegron (Myrbetriq) for Overactive Bladder
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Mirabegron (mir a beg’ ron; Myrbetriq [meer BEH trick] – Astellas), a beta-3 adrenergic agonist, has been approved by the FDA for the treatment of overactive bladder. It is the first beta-3 adrenergic agonist to be approved for any indication in the US. Mirabegron has been marketed in Japan since 2011. OnabotulinumtoxinA (Botox) was also recently approved by the FDA for treatment of overactive bladder and will be reviewed in a future issue.

STANDARD TREATMENT — Overactive bladder causes urgency, frequency, nocturia and incontinence, especially in older women. Behavioral modification, such as timed voiding, urge suppression and pelvic exercises, given sufficient time and effort, is probably the most effective treatment. Anticholinergic drugs, which bind to muscarinic receptors in the bladder, can relieve the symptoms of overactive bladder to some extent by inhibiting involuntary bladder ... more      

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