The Medical Letter on Drugs and Therapeutics
Raxibacumab for Anthrax
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The FDA has approved raxibacumab (rax” ee bak’ ue mab; GSK), a fully human monoclonal antibody given by intravenous infusion, for treatment of inhalational anthrax in combination with appropriate antibacterial drugs, and for prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate. It was approved under the Animal Efficacy Rule, which allows the FDA to approve drugs that demonstrate efficacy in animals, providing that they would have a reasonable human health benefit and are safe for human use. Raxibacumab is only available from the CDC.

STANDARD TREATMENT — The current management of a known or suspected inhalational exposure to anthrax in adults includes administration of anthrax vaccine adsorbed (AVA), an inactivated cell-free filtrate of an avirulent strain available from the CDC, in a series of 3 0.5-mL SC injections at 2-week intervals, and an appropriate antibiotic, ... more      

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