The Medical Letter on Drugs and Therapeutics
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1416
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Canagliflozin (Invokana) for Type 2 Diabetes

Canagliflozin (kan" a gli floe' zin; Invokana – Janssen), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has been approved by the FDA for oral treatment of type 2 diabetes.

DRUGS FOR DIABETES — Lifestyle modifications and metformin (Glucophage, and others) should be used first to treat patients with type 2 diabetes. If metformin alone fails to control hyperglycemia, there is no general agreement on which drug should be added next. Some available agents and their advantages and disadvantages are listed in Table 1. Many of these drugs are available in fixed-dose combinations with metformin. Most patients with type 2 diabetes eventually require multidrug therapy or insulin.1

SGLT2 INHIBITORS — Canagliflozin is the first SGLT2 inhibitor marketed in the US. ... more      

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