The Medical Letter on Drugs and Therapeutics
Omalizumab (Xolair) for Chronic Urticaria
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Omalizumab (Xolair) is a recombinant humanized monoclonal anti-IgE antibody currently approved by the FDA for treatment of moderate to severe persistent allergic asthma.1 It has been used off-label for treatment of allergic rhinitis and food allergies. Recently the results of a phase III clinical trial indicated that omalizumab may be effective in treating chronic urticaria as well.2

STANDARD TREATMENT — Second-generation H1-antihistamines are the current standard of care for chronic urticaria (hives that persist for ≥6 weeks).3,4 However, many patients do not respond to usual doses and some do not respond to up-dosing (off-label), even at 4 times the usual dose.5,6 Second-line agents include first-generation ... more      

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Title: Omalizumab (Xolair) for Chronic Urticaria
Article code: 1417b
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