The Medical Letter on Drugs and Therapeutics
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Liptruzet: A Combination of Ezetimibe and Atorvastatin

The FDA has approved a fixed-dose combination of the cholesterol absorption inhibitor ezetimibe and the HMG-CoA reductase inhibitor (statin) atorvastatin as Liptruzet (Merck) for treatment of hyperlipidemia. Ezetimibe is also available in a fixed-dose combination with simvastatin (Vytorin).1

CLINICAL STUDIES — FDA approval of Liptruzet was based on randomized, double-blind, controlled trials in patients with hyperlipidemia,2 heterozygous familial hypercholesterolemia, coronary heart disease or multiple cardiovascular risk factors,3 and one in patients with homozygous familial hypercholesterolemia. All of these trials used serum lipid levels as primary endpoints. Atorvastatin plus ezetimibe was more effective than twice the dose of atorvastatin alone ... more      

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