The Medical Letter on Drugs and Therapeutics
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1421
Brinzolamide/Brimonidine (Simbrinza) for Glaucoma
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The FDA has approved Simbrinza (Alcon), an ophthalmic combination of the carbonic anhydrase inhibitor brinzolamide and the selective alpha2-adrenergic receptor agonist brimonidine, for reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. Simbrinza is the first product to combine drugs from these 2 classes.

STANDARD TREATMENT — For initial treatment of glaucoma, a prostaglandin analog is preferred. Dosed once daily, prostaglandin analogs typically lower IOP by 25-30% and stabilize it at a lower level throughout the day and night. They have few, if any, systemic effects.

Topical beta blockers such as timolol are also commonly used; they lower IOP by 20-25% with once- or twice-daily dosing, but their use as first-line therapy has been limited by systemic adverse effects such as fatigue, dizziness, ... more      

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Title: Brinzolamide/Brimonidine (Simbrinza) for Glaucoma
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