The Medical Letter on Drugs and Therapeutics
Hydrocodone/Chlorpheniramine (Vituz)
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An oral solution (Vituz – Hawthorne) containing two old drugs, the centrally-acting opioid hydrocodone bitartrate and the first-generation H1-antihistamine chlorpheniramine maleate, has been approved by the FDA for relief of cough and [other] symptoms associated with upper respiratory allergies or a common cold in adults. Several extended-release products containing hydrocodone and chlorpheniramine are available as capsules and suspensions and have been used for years for similar indications. Vituz is classified as a schedule III controlled substance, but the FDA has asked the DEA to reclassify hydrocodone products as schedule II.

DRUGS FOR COUGH — Antitussives – Acute cough generally does not require treatment with drugs, especially in children, and suppression of productive cough may be harmful. Centrally-acting antitussives shown to be effective for cough include codeine, hydrocodone, ... more      

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Title: Hydrocodone Chlorpheniramine (Vituz)
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