The Medical Letter on Drugs and Therapeutics
Macitentan (Opsumit) for Pulmonary Arterial Hypertension
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The FDA has approved macitentan (ma" si ten' tan; Opsumit – Actelion), for oral treatment of pulmonary arterial hypertension (PAH). Macitentan is the second nonselective endothelin receptor antagonist approved for PAH. It is a derivative of bosentan (Tracleer), which is also manufactured by Actelion, and is scheduled to become available generically in 2015. Riociguat (Adempas), another new drug for this indication, will be reviewed in a future issue.

DRUGS FOR PAH — Current management of PAH usually includes warfarin (Coumadin, and others) and furosemide (Lasix, and generics). Oral drugs approved specifically for PAH include the phosphodiesterase 5 (PDE5) inhibitors sildenafil (Revatio, and generics) and tadalafil (Adcirca),1 bosentan, and ambrisentan (Letairis), a selective endothelin type A receptor ... more      

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Title: Macitentan (Opsumit) for Pulmonary Arterial Hypertension
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