The Medical Letter on Drugs and Therapeutics
Low-Dose Diclofenac (Zorvolex) for Pain
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The FDA has approved Zorvolex (Iroko), a low-dose oral formulation of the relatively COX-2 selective NSAID diclofenac, for treatment of mild-to-moderate acute pain in adults.

Zorvolex is available as 18- and 35-mg capsules. Other oral formulations of diclofenac include immediate-release, extended-release, and enteric-coated tablets and capsules in strengths ranging from 25 to 100 mg. Diclofenac is also available topically as a transdermal patch (Flector), a gel (Voltaren Gel), and a solution (Pennsaid).

THE NEW FORMULATION — Each capsule of Zorvolex contains diclofenac as submicron particles. The reduction in particle size increases surface area, leading to faster dissolution and absorption of the drug. A single-dose crossover study compared the new 35-mg formulation of diclofenac to diclofenac potassium 50 mg in healthy subjects. Taken without food, Tmax was about ... more      

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Title: Low-Dose Diclofenac (Zorvolex) for Pain
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