The Medical Letter on Drugs and Therapeutics
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1438
Mumps Outbreak
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An outbreak of mumps has occurred among students at Fordham University in New York. All of those who developed mumps had been vaccinated against the disease.

RECENT OUTBREAKS — Mumps outbreaks in the US have occurred predominantly in vaccinated older teenagers and young adults who are ≥10 years past their last measles-mumps-rubella (MMR) vaccination. Primary vaccine failure, close living conditions such as in college dormitories, and waning immunity could be contributing factors. The relatively low incidence in older people could be due to a lower level of exposure or superior immunity from natural infection. In an outbreak in New York in 2009-2010, most of the cases occurred in persons who had previously received 2 doses of MMR vaccine; post-exposure prophylaxis with a third dose of the vaccine was followed by a rapid decline in the incidence of disease. ... more      

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