The Medical Letter on Drugs and Therapeutics
Drugs for Gout
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The goals of gout treatment are threefold: treating acute inflammation, preventing flares, and lowering serum urate levels.1,2

ACUTE GOUT — Nonsteroidal anti-inflammatory drugs (NSAIDs) – In most patients without renal disease, peptic ulcer disease, or other contraindications, acute exacerbations of gout can be treated successfully with an NSAID, which should be started as soon as possible after the onset of symptoms and taken regularly (not as needed) until resolution of the flare. There is no convincing evidence that indomethacin (Indocin, and others), a traditional choice, is more effective than other NSAIDs such as ibuprofen (Motrin, and others) or naproxen (Naprosyn, and others). In one controlled trial, high doses of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex; 800 mg once, then 400 mg 12 hours later on day 1, ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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Title: Drugs for Gout
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