The Medical Letter on Drugs and Therapeutics
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1443
Eslicarbazepine Acetate (Aptiom) for Epilepsy
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Eslicarbazepine acetate (Aptiom – Sunovion) has been approved by the FDA for adjunctive treatment of partial-onset seizures in adults. New drugs for epilepsy are often approved by the FDA initially only as adjunctive treatment for partial seizures.1 Eslicarbazepine acetate is a prodrug of eslicarbazepine, which is the S-isomer of the active metabolite of oxcarbazepine. Oxcarbazepine itself is similar to carbamazepine. Both oxcarbazepine and carbamazepine are available generically.

MECHANISM OF ACTION — As with oxcarbazepine and carbamazepine, the antiepileptic activity of eslicarbazepine is believed to be due to inhibition of voltage-gated sodium channels, which reduces membrane excitability.2

CLINICAL STUDIES — Approval of eslicarbazepine acetate was based on the results of 3 randomized, ... more      

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