The Medical Letter on Drugs and Therapeutics
Oral Propranolol (Hemangeol) for Infantile Hemangioma
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The FDA has approved an oral solution of the nonselective beta-adrenergic blocker propranolol (Hemangeol – Pierre Fabre) for treatment of proliferating infantile hemangiomas.

INFANTILE HEMANGIOMAS — These benign congenital vascular tumors eventually tend to regress spontaneously, but early in life they can grow rapidly and can ulcerate, bleed, cause disfigurement, interfere with respiration or vision, and cause heart failure. Complicated infantile hemangiomas have been treated with systemic corticosteroids. Interferon alfa and vincristine are alternatives.

BACKGROUND — In a report describing 11 children with complicated infantile hemangiomas treated with propranolol (the first child was being treated for an associated condition), the color of the tumor changed within 24 hours from intense red to purple and its texture softened. Subsequently, the tumors continued to regress until they ... more      

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Title: Oral Propranolol (Hemangeol) for Infantile Hemangioma
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