The Medical Letter on Drugs and Therapeutics
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1460
Metreleptin (Myalept) - A Leptin Analog for Generalized Lipodystrophy
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Metreleptin (Myalept – Amylin), a recombinant leptin analog produced in E. coli, has been approved by the FDA to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy. It has not been approved to date for the treatment of partial lipodystrophies, including those associated with the use of protease inhibitors in patients with HIV. Metreleptin is approved in Japan for the treatment of any lipodystrophy disorder.

THE DISORDER — Generalized lipodystrophy is a rare disorder with fewer than 500 known cases in the world.1 Congenital and acquired generalized lipodystrophy are characterized by a near total lack of adipose tissue. Fat is deposited ectopically in muscle and liver tissue and can cause metabolic complications including insulin resistance, hyperinsulinemia, diabetes mellitus, and non-alcoholic fatty ... more      

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Title: Metreleptin (Myalept) - A Leptin Analog for Generalized Lipodystrophy
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