The Medical Letter on Drugs and Therapeutics
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1463
Tavaborole Topical Solution (Kerydin) for Onychomycosis
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The FDA has approved tavaborole 5% solution (Kerydin – Anacor Pharmaceuticals) for topical treatment of toenail onychomycosis due to Trichophyton rubrum or Trichophyton mentagrophytes. It is the first oxaborole antifungal drug to be approved for this indication.

STANDARD TREATMENT — Toenail onychomycosis is most often caused by the dermatophytes T. rubrum and T. mentagrophytes, and rarely by nondermatophyte molds and yeasts. Oral terbinafine and oral itraconazole are the drugs of choice for treatment of dermatophyte toenail onychomycosis, but even with prolonged treatment (3 months), cure rates are low and relapse rates are high. Drug interactions and adverse effects, including gastrointestinal symptoms, serious skin reactions, and severe hepatic toxicity are common.1,2 Terbinafine is generally preferred over ... more      

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Title: Tavaborole Topical Solution (Kerydin) for Onychomycosis
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