The Medical Letter on Drugs and Therapeutics
Testosterone Nasal Gel (Natesto) for Hypogonadism
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The FDA has approved an intranasal gel formulation of testosterone (Natesto – Trimel/Endo) for replacement therapy in men with hypogonadism. Packaged in a metered-dose pump, Natesto is the first intranasal testosterone to become available in the US. Like other testosterone products, it is classified as a schedule III controlled substance. The FDA recently cautioned against using testosterone to treat low testosterone levels solely due to aging because the benefits and safety of such use have not been established, and there is a possible increased risk of myocardial infarction (MI) and stroke.1

HYPOGONADISM — Failure of the testes to produce adequate amounts of testosterone can lead to loss of energy, irritability, depression, decreased libido, erectile dysfunction, decreased axillary and pubic hair, loss of muscle mass, anemia, and osteoporosis. Testosterone ... more      

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Title: Testosterone Nasal Gel (Natesto) for Hypogonadism
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