The Medical Letter on Drugs and Therapeutics
Nivolumab (Opdivo) for Metastatic Melanoma and Metastatic NSCLC
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The FDA has approved nivolumab (Opdivo – BMS), an IV programmed death receptor-1 (PD-1) blocking antibody, for treatment of unresectable or metastatic melanoma that has progressed following treatment with ipilimumab (and a BRAF inhibitor in patients who are BRAF V600 mutation positive) and for treatment of metastatic squamous non-small cell lung cancer (NSCLC) that has progressed on or after platinum-based chemotherapy. It is the second PD-1 inhibitor to be marketed in the US after pembrolizumab (Keytruda),1 and the first to be approved for treatment of NSCLC.

STANDARD TREATMENT — Metastatic melanoma – High-dose interleukin-2 (aldesleukin – Proleukin) has produced responses in 15-20% of patients with metastatic melanoma, but its use has been limited by severe toxicity and cumbersome administration requiring hospitalization for treatment. The ... more      

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Title: Nivolumab (Opdivo) for Metastatic Melanoma and Metastatic NSCLC
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