Psoriatic arthritis is a chronic inflammatory arthropathy that develops in up to 40% of patients with psoriasis. Several guidelines for treatment of psoriatic arthritis have been published.1-4

NSAIDs

Nonselective NSAIDs can improve symptoms in patients with mild disease. The selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex, and generics) may also be effective; one randomized, double-blind, 12-week trial in patients with a psoriatic arthritis flare found that ACR20 response rates (20% improvement on the American College of Rheumatology scale) with celecoxib 200 or 400 mg daily were superior to those with placebo at week 2, but there was no difference between the groups at week 12.5

Adverse Effects – Worsening of skin disease has been reported when NSAIDs were started in patients ... more      

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