The Medical Letter on Drugs and Therapeutics
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1473
Namzaric - A Combination of 2 Old Drugs for Alzheimer's Disease
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The FDA has approved Namzaric (Forest), a fixed-dose combination of extended-release (ER) memantine (Namenda XR), an NMDA-receptor antagonist, and donepezil (Aricept, and generics), an acetylcholinesterase inhibitor, for treatment of moderate to severe Alzheimer's type dementia in patients previously stabilized on both drugs. The patent for Namenda has recently expired and generic formulations of memantine 5- and 10-mg tablets have been approved.

STANDARD TREATMENT — Acetylcholinesterase inhibitors and memantine are the only drugs currently available for treatment of Alzheimer's disease (AD). They have produced modest but apparently persistent improvements in cognition, activities of daily living, and behavior. None of these agents have been shown to stop or reverse the underlying neurodegenerative process.1

Many patients with moderate ... more      

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Title: Namzaric - A Combination of 2 Old Drugs for Alzheimer's Disease
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