The Medical Letter on Drugs and Therapeutics
Rifaximin (Xifaxan) for Irritable Bowel Syndrome with Diarrhea
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Rifaximin (Xifaxan – Salix), a minimally absorbed oral antibiotic approved previously to treat travelers' diarrhea and to reduce the risk of recurrent hepatic encephalopathy, has now been approved by the FDA for treatment of irritable bowel syndrome with diarrhea (IBS-D). Eluxadoline (Viberzi – Actavis), a mu-opioid receptor agonist, was also recently approved for IBS-D and will be reviewed in a future issue.

SOME TREATMENTS FOR IBS — Symptoms of IBS can include abdominal pain, bloating, flatulence, diarrhea, and constipation. Extra-intestinal complaints are also common. IBS is subtyped, according to the predominant bowel symptom, as IBS with diarrhea (IBS-D), IBS with constipation (IBS-C), mixed-type (IBS-M), or unclassified (IBS-U). The goal of treatment is symptom control; dietary modifications may help improve symptoms of all subtypes of IBS.

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Title: Rifaximin (Xifaxan) for Irritable Bowel Syndrome with Diarrhea
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