The Medical Letter on Drugs and Therapeutics
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Influenza Vaccine for 2015-2016

Annual vaccination against influenza A and B viruses is recommended for everyone ≥6 months old without a specific contraindication.1

EFFECTIVENESS — The effectiveness of the seasonal vaccine in preventing influenza in healthy adults depends on the match between the vaccine and circulating strains. Vaccine effectiveness is highest (50-80% in young adults; lower in the elderly) when the match is close, but even when the match is poor, vaccination has been shown to reduce the risk of laboratory-confirmed influenza, hospitalization for influenza, and death.2,3

Quadrivalent vs Trivalent – All of the trivalent and quadrivalent seasonal influenza vaccines available in the US contain the same two influenza A virus antigens. Trivalent vaccines contain only one influenza B virus antigen. Quadrivalent vaccines contain ... more      

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