The Medical Letter on Drugs and Therapeutics
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1479
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SGLT2 Inhibitors: New Reports

The recent report of a reduction in cardiovascular mortality in patients with type 2 diabetes treated with the SGLT2 inhibitor empagliflozin (Jardiance) was published soon after the FDA issued new warnings about an increased risk of fractures with canagliflozin (Invokana).

SGLT2 INHIBITORS — SGLT2 (sodium-glucose co-transporter 2), a membrane protein expressed mainly in the kidney, transports filtered glucose from the proximal renal tubule into tubular epithelial cells. SGLT2 inhibitors decrease renal glucose reabsorption and increase urinary glucose excretion, resulting in lower blood glucose levels that are independent of insulin secretion and a modest reduction in HbA1c. These drugs also increase urinary sodium excretion, cause weight loss, and lower blood pressure.

View our detailed online table: SGLT-2 ... more      

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