The Medical Letter on Drugs and Therapeutics
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1481
Two Long-Acting Injectable Antipsychotics for Schizophrenia
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The FDA has approved two new long-acting injectable formulations of second-generation antipsychotics for treatment of schizophrenia: aripiprazole lauroxil (Aristada – Alkermes), which is given once every 4-6 weeks, and paliperidone palmitate (Invega Trinza – Janssen), which is given once every 3 months. Once-monthly injectable formulations of aripiprazole (Abilify Maintena) and paliperidone palmitate (Invega Sustenna) were approved earlier.1,2

SECOND-GENERATION ANTIPSYCHOTICS — Second-generation antipsychotics are used more commonly than first-generation drugs, even though controlled trials have failed to demonstrate a clear advantage in efficacy with the newer drugs, except for clozapine (Clozaril, and others) and possibly olanzapine (Zyprexa, and others). Because of its potential for serious toxicity, clozapine, the ... more      

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Title: Two Long-Acting Injectable Antipsychotics for Schizophrenia
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