The Medical Letter on Drugs and Therapeutics
Transdermal Fentanyl (Ionsys) for Postoperative Pain
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A patient-controlled fentanyl iontophoretic transdermal system (Ionsys – The Medicines Company) is now available for short-term management of acute postoperative pain in adults requiring opioid analgesia in the hospital. Before using Ionsys, patients must be titrated to a comfortable level of analgesia with another opioid formulation.

THE DEVICE — The fentanyl iontophoretic transdermal system (ITS) has two parts: a drug unit and a controller containing the battery and electronics. The single-use, disposable device, which is about the size of a credit card, is attached to the patient's skin by an adhesive strip. A button on the controller activates a low-intensity electric current that drives a fixed dose of fentanyl ions from a hydrogel reservoir through the skin and into the systemic circulation.

PHARMACOKINETICS – The pharmacokinetic profile of transdermal fentanyl ... more      

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Title: Transdermal Fentanyl (Ionsys) for Postoperative Pain
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