The Medical Letter on Drugs and Therapeutics
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1486
Durlaza - A 24-Hour Extended-Release Aspirin
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The FDA has approved Durlaza (New Haven Pharmaceuticals), a 24-hour extended-release (ER) aspirin formulation available only by prescription, for secondary prevention of myocardial infarction (MI) and stroke.

RATIONALE — Aspirin's antiplatelet effects are irreversible and persist for the life of the platelet. Immediate-release (IR) aspirin is cleared from serum within 6 hours after a dose. New platelets released into the systemic circulation after IR aspirin is cleared will be active until the next dose is taken. Patients with diabetes and coronary artery disease (CAD) may have high platelet turnover; a study in patients with CAD and type 2 diabetes treated with once-daily low-dose IR aspirin found increased platelet aggregation at the end of the 24-hour dosing interval.1 An ER formulation that releases acetylsalicylic acid (ASA) over a 24-hour period could inhibit ... more      

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Title: Durlaza - A 24-Hour Extended-Release Aspirin
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