ISSUE 1487
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The pathogenesis of acne is multifactorial: follicular hyperkeratinization, bacteria, sebum production, androgens, and inflammation all play a role. The gram-positive microaerophilic bacteria Propionibacterium acnes promotes development of acne lesions by secreting chemotactic factors that attract leukocytes to the follicle, causing inflammation.
TOPICAL THERAPY — Salicylic Acid – Widely available over the counter (OTC), topical salicylic acid is a well-tolerated keratolytic agent that can be used alone or in combination with other drugs such as benzoyl peroxide.
Benzoyl Peroxide – The oxidizing agent benzoyl peroxide is available in a wide variety of OTC and prescription preparations for treatment of mild to moderate acne. Its effect is primarily due to its antibacterial activity against P. acnes. Benzoyl peroxide is often used in combination with topical or oral antibiotics. It
... more- SE Garner et al. Minocycline for acne vulgaris: efficacy and safety. Cochrane Database Syst Rev 2012; 8:CD002086.
- AO Arowojolu et al. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst Rev 2012; 7:CD004425.
- EA Arrington et al. Combined oral contraceptives for the treatment of acne: a practical guide. Cutis 2012; 90:83.
- GK Kim and JQ Del Rosso. Oral spironolactone in post-teenage female patients with acne vulgaris: practical considerations for the clinician based on current data and clinical experience. J Clin Aesthet Dermatol 2012; 5:37.
- CB Turowski and WD James. The efficacy and safety of amoxicillin, trimethoprim-sulfamethoxazole, and spironolactone for treatment-resistant acne vulgaris. Adv Dermatol 2007; 23:155.
- HC Williams et al. Acne vulgaris. Lancet 2012; 379:361.
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