The Medical Letter on Drugs and Therapeutics
Patiromer (Veltassa) for Hyperkalemia
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Revised 12/7/16: In the Drug Interactions paragraph, a sentence was added about a November 2016 revision in the prescribing information.

The FDA has approved patiromer (Veltassa – Relypsa), an oral potassium binder, for treatment of hyperkalemia. It is the first drug to be approved for this indication since the cation-exchange resin sodium polystyrene sulfonate (Kayexalate, and others) in 1958. Patiromer is not indicated for emergency correction of life-threatening hyperkalemia. Sodium zirconium cyclosilicate, another oral potassium binder, is currently being reviewed by the FDA; a decision on its approval is expected in May 2016.

HYPERKALEMIA — Hyperkalemia (serum potassium level >5.0 mEq/L) can occur in patients with renal disease or in those taking drugs that inhibit the renin-angiotensin-aldosterone system (RAAS) such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), direct renin inhibitors, and aldosterone antagonists. Dosage reduction or discontinuation of RAAS inhibitors because ... more      

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