The Medical Letter on Drugs and Therapeutics
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Seebri Neohaler and Utibron Neohaler for COPD

The FDA has approved two new inhalers for long-term maintenance treatment of chronic obstructive pulmonary disease (COPD). Seebri Neohaler (Novartis) contains the long-acting anticholinergic glycopyrrolate. Utibron Neohaler (Novartis) contains both glycopyrrolate and the long-acting beta2-adrenergic agonist (LABA) indacaterol. Glycopyrrolate/indacaterol is the third fixed-dose combination of a long-acting anticholinergic and a LABA to become available in the US; umeclidinium/vilanterol (Anoro Ellipta)1 and tiotropium/olodaterol (Stiolto Respimat)2 were approved earlier.

GLYCOPYRROLATE — Glycopyrrolate has been available for many years in a parenteral formulation for multiple indications. An oral formulation is available for reduction of chronic severe drooling in children with certain ... more      

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