The Medical Letter on Drugs and Therapeutics
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1492
Dichlorphenamide (Keveyis) for Periodic Paralysis
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Dichlorphenamide (Keveyis – Taro), an oral carbonic anhydrase inhibitor, has been approved by the FDA for treatment of primary hypokalemic and hyperkalemic periodic paralysis and related variants. Dichlorphenamide is the first drug to be approved in the US for this indication. It was approved as Daranide in 1958 for treatment of glaucoma, but had not been marketed since 2002.

THE DISEASE — Periodic paralysis is a rare hereditary disorder caused by sodium or calcium channel defects in skeletal muscle. The disease is characterized by episodes of muscle weakness, paralysis, and often hypo- or hyperkalemia. Acetazolamide (Diamox, and generics), another oral carbonic anhydrase inhibitor, has been used off-label for treatment of periodic paralysis for years; in an observational study, 34 of 74 patients with hypokalemic periodic paralysis (46%) benefited from acetazolamide ... more      

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Title: Dichlorphenamide (Keveyis) for Periodic Paralysis
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