The Medical Letter on Drugs and Therapeutics
Drugs for Multiple Sclerosis
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Most patients with multiple sclerosis (MS) present with the relapsing-remitting form of the disease.1 Treatment usually includes disease-modifying drugs, various other drugs for managing symptoms such as fatigue, depression, and pain, and corticosteroids for acute exacerbations.

INJECTABLE AGENTS — Interferons – Interferon beta was the first disease-modifying drug approved for treatment of MS. Interferons have several immune-modulating and anti-inflammatory effects. They can reduce clinical relapse rates by 30-35% and decrease the number of new T2 or gadolinium-enhancing brain lesions seen on MRI. Whether these effects delay or prevent long-term disability is unclear.2,3 Interferons frequently cause injection-site reactions and a flu-like syndrome.4 Pegylated interferon beta-1a (Plegridy) injected ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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Title: Drugs for Multiple Sclerosis
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